Starter Guide · Canada

Tirzepatide or Retatrutide?

Two GLP-class peptides with different dose ladders, timelines, and starting points.

Established

Tirzepatide

GLP-1 / GIP · 6-step ladder over 21+ weeks

Doses 2.5 → 15 mg
Step size 2.5 mg increments
Pen kits 5 / 10 / 15 mg
Price range $95 – $225
  • Smaller dose steps — easier to titrate up
  • Most clinical data of the two compounds
  • Highest appetite suppression
See Tirz starter guide → Next Gen

Retatrutide

GLP-1 / GIP / Glucagon · 4-step ladder over 13+ weeks

Doses 2 → 12 mg
Step size Doubling each step
Pen kits 4 / 8 / 12 mg
Price range $120 – $285
  • Triple-action mechanism — strongest reported results
  • Larger dose jumps — hold each step 4 weeks
  • Best fit if Tirz has plateaued for you
See Reta starter guide →

Tirzepatide Starter Guide

Swipe or tap a dose to see EZpen options →

Step 1 Start Here 2.5 mg once weekly Weeks 1–4 Use 5mg EZpen View EZpen options → Step 2 5 mg once weekly Weeks 5–8 Use 5mg or 10mg EZpen View EZpen options → Step 3 7.5 mg once weekly Weeks 9–12 Use 10mg or 15mg EZpen View EZpen options → Step 4 10 mg once weekly Weeks 13–16 Use 10mg or 15mg EZpen View EZpen options → Step 5 12.5 mg once weekly Weeks 17–20 Use 15mg EZpen View EZpen options → Step 6 15 mg once weekly Week 21+ Use 15mg EZpen View EZpen options →

Which EZpen covers each dose? Hover a dose above to highlight.

5mg EZpen 2.5mg–5mg 5
10mg EZpen 5mg–10mg 10
15mg EZpen 7.5mg–15mg 15

Retatrutide Starter Guide

Swipe or tap a dose to see EZpen options →

Step 1 Start Here 2 mg once weekly Weeks 1–4 Use 4mg EZpen View EZpen options → Step 2 4 mg once weekly Weeks 5–8 Use 4mg or 8mg EZpen View EZpen options → Step 3 8 mg once weekly Weeks 9–12 Use 8mg or 12mg EZpen View EZpen options → Step 4 12 mg once weekly Week 13+ Use 12mg EZpen View EZpen options →

Which EZpen covers each dose? Hover a dose above to highlight.

4mg EZpen 2mg–4mg 4
8mg EZpen 4mg–8mg 8
12mg EZpen 8mg–12mg 12
Titration

When to stop moving up

Higher isn’t automatically better. The goal is the lowest dose that keeps working for you — not the top of the ladder.

  • Still controlling your appetite? Stay there. Only step up once that effect has clearly faded.
  • Hold each new dose the full 4 weeks before deciding — give it time to settle.
  • Stop climbing if side effects start to outweigh the benefit, or you’ve hit the rate of progress you’re after.

Plenty of people settle below the highest dose — that’s completely normal.